Quinine Sulphate

Quinine Sulphate

Quinine is a natural white crystalline alkaloid which has antipyrettic, antimalarial, analgesic, anti inflammatory properties and  a bitter taste. The natural source of Quinine is Cinchona tree. Our pharmacist have developed this useful drug named as Quinine Sulphate. These are proven to be effective in curing various types of illness. Many medical experts prescribe this drug for quick healing of patients.          Some specifications related to Quinine are as follows:

Identifiers

CAS number                        130-95-0

ATC code                             M09AA01 P01BC01

PubChem                             CID 8549

DrugBank                            DB00468

ChemSpider                        84989 

UNII A                                  7V27PHC7A

KEGG                                D08460 

ChEMBL                           CHEMBL170 

Chemical data

Formula                              C20H24N2O2 

Mol. mass                             324.417 g/mol

SMILES                               eMolecules & PubChem

Physical data

Melt. point                             177 Ã‚°C (351 Ã‚°F)

Pharmacokinetic data

Bioavailability                           76 to 88%

Protein binding                              ~70%

Metabolism Hepatic (mostly CYP3A4 and CYP2C19-mediated)

Half-life                                   ~18 hours Excretion Renal (20%)

Therapeutic considerations            Pregnancy cat. C (USA), D (Au)

Legal status quinine is now banned in Australia unless specifically for malaria due to its tendency to kill blood platelets.